Sail Central America from Atlantic to Pacific
View natural beauty and an engineering marvel across the Panama Canal
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Featured Panama Canal Cruises
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10 Night Panama Canal
Carnival Legend
Departing from: Galveston, TexasPorts of Call:- Cozumel, Mexico
- Puerto Limon, Costa Rica
- Colon, Panama
- Mahogany Bay (Roatan), Bay Islands, Honduras
Sailing Dates:- October 2025
- December 2025
- March 2026
interior from$984$98pernightoceanview from$1,324$132pernightbalcony from$1,669$167pernightsuite from$3,515$352pernightInterior from $984($98pernight)3.9 rating out of 5 (2,210 reviews) -
8 Night Panama Canal
Carnival Legend
Departing from: Tampa, FloridaPorts of Call:- Puerto Limon, Costa Rica
- Colon, Panama
- George Town, Grand Cayman
Sailing Dates:- January 2027
- March 2027
interior from$1,039$130pernightoceanview from$1,189$149pernightbalcony from$1,389$174pernightsuite from$2,231$279pernightRewards & Bonus Offers:Interior from $1,039($130pernight)3.9 rating out of 5 (2,210 reviews) -
16 Night Panama Canal Carnival Journeys - Eastbound
Carnival Spirit
Departing from: Seattle, WashingtonPorts of Call:- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- New Orleans, Louisiana
Sailing Dates:- October 2025
interior from$993$62pernightoceanview from$1,333$83pernightbalcony from$1,628$102pernightsuite fromCall for availabilityInterior from $993($62pernight)4 rating out of 5 (998 reviews) -
12 Night Panama Canal Discovery: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- October 2025
- December 2025
- February 2026
- March 2026
interior from$1,199$100pernightoceanview from$1,699$142pernightbalcony from$1,899$158pernightsuite from$2,899$242pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Up to 30% Savings + Up to $300 to Spend on Board
- Exclusive: Free Tamarind Dinner for 2 - Call
- AAdvantage® Credit Cardmembers get even more miles
- Free Drinks, Dining, and Excursions with Select Fares
- Free or Reduced Fares for Guests 3 & 4!
- Call for rates too low to show!
Interior from $1,199($100pernight)4.4 rating out of 5 (290 reviews) -
16 Night Panama Canal - Eastbound
Celebrity Summit
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Falmouth, Jamaica
- George Town, Grand Cayman
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior fromCall for availabilityoceanview from$1,617$101pernightbalcony from$2,867$179pernightsuite from$17,377$1,086pernightWas $6,291 – Save up to 74%Oceanview from $1,617($101pernight)4.1 rating out of 5 (2,265 reviews) -
11 Night Panama Canal Partial Transit: Mexico Costa Rica & Belize
Norwegian Jewel - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
- March 2026
interior from$1,330$121pernightoceanview from$1,520$138pernightbalcony from$2,380$216pernightsuite from$2,679$244pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Limited-Time: Up to 25,000 AAdvantage® Bonus Miles
- Save up to $250 Instantly! Call and Mention: CruiseFirst
- AAdvantage® Credit Cardmembers get even more miles
- Reduced Fares for Third & Fourth Guests
- 50% Off All Cruises + Enhanced More at Sea Perks
Interior from $1,330($121pernight)3.7 rating out of 5 (2,431 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- George Town, Grand Cayman
- Falmouth, Jamaica
- Puerto Limon, Costa Rica
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
Sailing Dates:- November 2025
interior from$1,238$103pernightoceanview from$1,318$110pernightbalcony from$1,948$162pernightsuite from$2,398$200pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Exclusive: Free Onboard Savings Booklet - up to a $1,800 value!
- Exclusive: Up to $100 to Spend on Board - Call
- AAdvantage® Credit Cardmembers get even more miles
- Spring Sale: Up to 50% Off, Free Upgrades & More
- Drinks, Tips & Wi-Fi Included with Select Fares
- Call for rates too low to show!
Interior from $1,238($103pernight)3.9 rating out of 5 (1,921 reviews) -
16 Night Panama Canal - Ocean to Ocean
Caribbean Princess
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puntarenas, Costa Rica
- Panama City (Fuerte Amador), Panama
- Panama Canal Full Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior from$1,298$81pernightoceanview from$1,378$86pernightbalcony from$2,078$130pernightsuite from$2,818$176pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Exclusive: Free Onboard Savings Booklet - up to a $1,800 value!
- AAdvantage® Credit Cardmembers get even more miles
- Exclusive: Earn up to 20,000 bonus miles!
- Spring Sale: Up to 50% Off, Free Upgrades & More
- Drinks, Tips & Wi-Fi Included with Select Fares
- Call for rates too low to show!
Interior from $1,298($81pernight)3.9 rating out of 5 (1,921 reviews) -
13 Night Panama Canal Eastward
Serenade of the Seas
Departing from: San Diego, CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- September 2025
interior from$1,508$116pernightoceanview from$1,928$148pernightbalcony from$5,910$455pernightsuite fromCall for availabilityWas $3,028 – Save up to 50%Interior from $1,508($116pernight)4.1 rating out of 5 (1,829 reviews) -
15 Night Panama Canal: Mexico Costa Rica & Colombia
Norwegian Joy - OPEN BAR!
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Cabo San Lucas, Mexico
- Acapulco, Mexico
- Puerto Quetzal, Guatemala
- Puerto Caldera (Puntarenas), Costa Rica
- Panama City, Panama
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- October 2025
interior from$1,671$111pernightoceanview from$2,101$140pernightbalcony from$2,871$191pernightsuite from$2,951$197pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Limited-Time: Up to 25,000 AAdvantage® Bonus Miles
- Save up to $250 Instantly! Call and Mention: CruiseFirst
- AAdvantage® Credit Cardmembers get even more miles
- 50% Off All Cruises + Enhanced More at Sea Perks
- No Interest or Approval: Book with No Cruise Payment Due Today
Interior from $1,671($111pernight)4.2 rating out of 5 (998 reviews) -
11 Night Panama Canal: Mexico Costa Rica & Belize
Norwegian Pearl - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- Ocho Rios, Jamaica
- Cartagena, Colombia
- Cruise Gatun Lake And Panama Canal
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
interior from$1,662$151pernightoceanview from$2,012$183pernightbalcony from$3,112$283pernightsuite from$3,212$292pernightInterior from $1,662($151pernight)3.8 rating out of 5 (2,075 reviews) -
12 Night Panama Canal Holiday: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Ocho Rios, Jamaica
Sailing Dates:- December 2025
interior from$1,799$150pernightoceanview from$2,299$192pernightbalcony from$2,599$217pernightsuite from$3,899$325pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Up to 30% Savings + Up to $300 to Spend on Board
- AAdvantage® Credit Cardmembers get even more miles
- Free Drinks, Dining, and Excursions with Select Fares
- No Interest or Approval: Book with No Cruise Payment Due Today
- Call for rates too low to show!
Interior from $1,799($150pernight)4.4 rating out of 5 (290 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean Holiday
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Oranjestad, Aruba
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- December 2025
interior from$1,798$150pernightoceanview from$2,038$170pernightbalcony from$3,098$258pernightsuite from$3,818$318pernightRewards & Bonus Offers:- AAdvantage® Members: Earn 2X Miles on Select Sailings
- Exclusive: Free Onboard Savings Booklet - up to a $1,800 value!
- Exclusive: Up to $100 to Spend on Board - Call
- AAdvantage® Credit Cardmembers get even more miles
- Spring Sale: Up to 50% Off, Free Upgrades & More
- Drinks, Tips & Wi-Fi Included with Select Fares
- Call for rates too low to show!
Interior from $1,798($150pernight)3.9 rating out of 5 (1,921 reviews) -
11 Night Panama Canal & Southern Caribbean
Celebrity Ascent
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
- Kralendijk, Bonaire
Sailing Dates:- March 2026
interior from$2,587$235pernightoceanview from$2,970$270pernightbalcony from$3,604$328pernightsuite fromCall for availabilityWas $6,404 – Save up to 60%Interior from $2,587($235pernight)4.6 rating out of 5 (98 reviews)
Panama Canal Cruises ... Unbeatable Vacations For Less
Enjoy Huge Savings & Offers on Panama Canal Cruises
Perhaps your Panama Canal cruise vacation will take you through the port of Huatulco, Mexico, where quaint villages meet upscale resorts - plus plenty of white-sand beaches to enjoy the waters of paradise. Enjoy a livelier environment in Cabo San Lucas, and dine at the world-renown Cabo Wabo Cantina Concert Hall & Restaurant, owned by rocker, Sammy Hagar. If you'd prefer to spend your time enjoying all the water sports that a Panama Canal cruise has to offer, don't miss the unbeatable scuba diving and snorkeling opportunities in Puntarenas, Costa Rica.
Regardless of which fantastic Panama Canal cruise itinerary you choose, you're sure to experience luxurious accommodations, fine dining options and daily entertainment aboard your cruise ship. Why settle for the hassle of multiple hotel stays and inconvenient transportation when you can have it all with a cruise vacation? Simply book your Panama Canal cruise getaway through American Airlines Cruises, and take advantage of the best prices and deals around.
Search Panama Canal Cruises
- Azamara Cruises from $2,339
- Celebrity Cruises from $1,617
- Cunard from $1,529
- Holland America Line from $1,199
- Norwegian Cruise Line from $1,330
- Oceania Cruises from $2,325
- Ponant from $5,480
- Princess Cruises from $790
- Regent Seven Seas Cruises from $9,199
- Royal Caribbean from $1,205
- Seabourn from $5,799
- Silversea Cruises from $6,400
- Viking Ocean Cruises from $3,299
- Windstar Cruises from $2,615
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